The Nile Research Institute (NRI), affiliate to the National Water Research Center (NWRC), has developed and designed an integrated information system for the Nile River and its branches in Egypt, through the construction of comprehensive Geographic Information System (GIS) databases containing spatial data in a single environment that is easy to deal with and can be faster accessed to help in making the right decisions necessary to manage and develop the Nile River in Egypt and save time, effort and cost. This update and the integrated system has the ability to manage, analyze and control spatial and non-spatial data in addition to the creation of integrated databases, where the locations and data of all the different structures on the Nile River and its branches (facilities, services and projects) are available through data from NRI (Technical Studies - Technical Reports - topographic maps - Nile water levels and discharges). This system demonstrates the importance of integrating multiple capabilities of GIS with programming languages in developing a comprehensive Nile river information system that has the ability to access, modify, search, analyze and process the database, which subsequently affects positives the decision-making. The database system includes the following Geographic database: 1. Database of Nile River water levels and discharges available at the NRI 2. Electricity, telephones, and fiber optic cables passing through the Nile River and its branches 3. Gas, oil and subway lines passing through the Nile River and its branches 4. Ship anchors located on the Nile River and its branches 5. Water stations and power plants located on the Nile River and its branches 6. Ports located on the Nile River and its branches 7. Geographic database of power stations located on the Nile River and its branches 8. The locations and data of water quality monitoring stations located on the Nile River and its branches. Currently, construction and insertion of geographic databases of river islands, and sedimentation basins along the Nile and its branches are taking place. The updated system features an easy user interface that saves time and effort in extracting any data and information in an easy and accurate way.